Courses
Course Code and Number, Course Title, Credit(s) TOXI 601 and 602 Advanced Toxicology I and II (3, 3)*
Lectures and discussions cover principles of toxicology. Topics include major classes of toxic agents, principal target organs of toxicity, and mechanisms of toxicity. A two-semester course.
Prerequisites: biochemistry and physiology at the 300 or higher level, or consent of instructor. TOXI 603 Fundamentals in Pharmacology (2)
This introductory course, required in all tracks, deals with basic principles of drug action. Topics include quantitation of drug-receptor interactions, drug distribution and elimination, and molecular chemotherapeutic mechanisms. A background in biochemistry or physiology is helpful.
Prerequisites: MPHY 644 the first five weeks of the semester.
Nondegree students: consent of the instructor TOXI 604 Biochemical Pharmacology (3)*
Covers biochemical and molecular mechanisms of drug, xenobiotic, and hormone action on cells and tissues. Emphasis is on methodology in pharmacological research. Topics include mechanisms of drug metabolism, enzymes as targets of drug action, interactions of drugs with channels and carriers, and drugs that interact with nuclear receptors. Offered spring semester, even-numbered years.
Prerequisite: GPLS 607 TOXI 607 Forensic Toxicology (3)
Lectures include discussion of principles underlying forensic and clinical toxicology, mechanism of action of drugs and other poisons, methods of detection and quantitation of drugs and poisons in tissues and body fluids, and interpretation of analytical procedures for the detection and estimation of drugs and chemicals in biological samples.
Prerequisites: organic chemistry, physical chemistry, quantitative analysis, and calculus. TOXI 608 Research in Toxicology (2-4)
Designed for students without previous research experience, this course provides training in how to design and conduct research studies, beginning with a two week classroom based introduction to hypothesis driven research and experimental approaches used in mechanistic studies in toxicology. For the remainder of the semester, each student will work individually with a faculty mentor to develop and complete a small lab-based or epidemiology research project. A written report will be generated and results of the project presented at the end of the semester seminar. TOXI 609 Methods in Toxicology (1-3)
Permission and credit arranged individually. Students become familiar with laboratory methods used by staff members to study the effect of toxins and environmental pollutants on living systems. Students may take for credit more than once. TOXI 615 Toxic Cell Injury (2)
Lectures concerning mechanisms of cell injury from toxic agents attempt to further integrate ideas from TOXI 601 and 602 using a cell biology approach to understanding how organic and inorganic toxicants produce cellular damage.
Prerequisites: TOXI 601 and 602, or consent of instructor. TOXI 616 Integrative Pharmacology (3)
A comprehensive introduction to the major classes of drug action, required in all tracks. The course relates cellular and molecular mechanisms to drug action at the level of organ systems and the intact organism, emphasizing research methods. Offered spring semester.
Prerequisites: GPLS 607, GPLS 641 or consent of instructor TOXI 618 Seminar in Toxicology (1)
Students, guests, and faculty members review and discuss original works and recent advances in toxicology. Students may take for credit more than once. TOXI 620 Joint Environmental Law-Toxicology Seminar Series on Special Topics (2)
Examines real-world problems involving toxic chemicals from both the legal and scientific perspectives. Law and toxicology students work as teams to develop innovative approaches to solving complex problems of regional and national interest. Topics include the effects of toxic chemicals on the Chesapeake Bay and public health problems associated with lead exposure. TOXI 621 Risk Assessment and Management in a Regulatory Context (3)
This course is designed to teach students the basic principles that apply to risk assessment of the environmental and human health effects of hazardous chemicals. The course features both lectures and case studies to introduce students to environmental regulations that impact the use, environmental release and clean up of chemical contaminants. Student will learn how to evaluate relationships between exposure to chemicals and health outcomes and how regulations are developed to protect human health.
Crosslisted: ELS Risk Assessment and Management in a Regulatory Context (School of Law) TOXI 622: Critical Issues in Law and Science (3)
This course is designed to teach students about how lawyers, managers and scientists make decisions about controlling the human health effects of environmental pollution. What roles do each of these players have in this process and when are decisions based on science versus policy? Through lectures, class discussions and role play scenarios, students will be taught to understand the underlying assumptions used in making regulatory decisions and will wrestle with difficult issues such as: When should the Precautionary Principle be applied? How well do we handle data gaps? Should human testing be allowed? Is our legal system utilizing science in an appropriate manner?
Crosslisted: ELS Critical Issues in Law and Science (School of Law) TOXI 623 Neurotoxicology (3)
A comprehensive foundation course suitable for graduate students concentrating in neuroscience or toxicology. Following a brief introduction to the normal structure and function of the cellular targets of neurotoxicants, the major classes of environmental neurotoxicants will be discussed in detail. Pesticide, industrial solvents, neurotoxic metals and biological neurotoxins will be studied from a concentration of environmental and occupational sources of exposure to cellular toxic mechanisms.
Prerequisite: Consent of instructor TOXI 625 Principles of Aquatic Toxicology (3)
Considers the effects and mechanisms by which chemicals produce toxic effects in aquatic organisms. The course covers toxicology testing methods, chemical disposition in aquatic species, metabolism, and biochemical effects at the subcellular level.
Prerequisite: TOXI 601 or equivalent TOXI 675 Reproductive and Developmental Toxicology (2)
Provides an overview of normal and abnormal male and female reproduction and embryo, fetal, and neonatal development, and covers regulatory toxicology issues, in particular focusing on the risk assessment process.
Prerequisite: TOXI 601 or equivalent TOXI 799 Master's Thesis Research (1-6) TOXI 899 Doctoral Dissertation Research (1-12) *A permission slip from the program director or instructor is necessary to enroll in this course.
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